PhD Position “Modulators of Light Chain Protein Aggregation in Amyloidosis” in the interdisciplinary “GERAMY” research consortium studying mechanisms and new treatment options in light chain amyloidosis. GERAMY – the German consortium for systemic light chain amyloidosis is a collaborative project funded by the Federal Ministry for Education and Research in its Rare Disease Program. Participating groups are located at the University of Heidelberg, Technische Universität München, Max Planck Research Unit Halle, University of Kiel and Washington University.The project “Modulators of Light Chain Protein Aggregation in Amyloidosis” (Reference GER TP7 MDC) will focus on the identification of chemical compounds that act on light chain aggregates. Cell free and cell based assays will be established to test a focused chemical library. Effective substances will be investigated in more detail in biochemical, biophysical and cell biological validation experiments.
The successful candidate has completed a Master’s degree or equivalent in a relevant discipline and has strong foundations in protein biochemistry and cell biology techniques. Experience/ interest in chemistry and biophysics are advantageous. This project will be carried out at the MDC, collaboration with the other consortium partners will be part of the activities.